There is a highly significant correlation between serum albumin level and mortality risk when stratified for age and gender. 25 In the literature, expansion of interstitial space is generally linked to increased transcapillary escape of plasma constituents into the interstitium, despite findings in experimental endotoxin‐treated animals that lymphatic backflow from the interstitium is also increased. 26 Fibrinogen yields fibrin after leaving the vascular space due to the simultaneous escape of clotting factors.
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