Equivalent Efficacy and Decreased Rate of Overcorrection in Patients With Syndrome of Inappropriate Secretion of Antidiuretic Hormone Given Very Low-Dose Tolvaptan.

Both our cohort and that of Morris et al had a highly significant paired 2-tailed t test for Na + 1 ≠ Na + 2 ( P < 0.0001).

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In the Morris et al cohort, percentages of patients who overcorrected were 28.6% at >12 mEq/L, 35.7% at >10 mEq/L, and 39.3% at >8 mEq/L per day compared with our cohort, in which the percentage of patients overcorrecting was 5.6% at >12 mEq/L, 5.6% at >10 mEq/L, and 11.1% at >8 mEq/L The delta [Na + ] of 12 mEq/L within a day was trending toward significance among the cohorts at P = 0.07.

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The study also shows that there is a statistically significantly decreased tendency for overcorrection at 8 mEq/L within a day compared with the data of Morris et al, 20 who administered 15 mg per day, with a trend toward significance at [Na + ] of 12 mEq/L within a day.

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