Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate.

These results are highly significant because they suggest that bisphosphonates could reverse cochlear synaptopathy for the treatment of SNHL. auditory nerve cochlear synaptopathy noise-induced hearing loss hidden hearing loss bisphosphonate synapse regeneration mevalonate pathway drug repurposing Here, we used this type of neuropathic noise exposure to evaluate whether systemic administration of zoledronate after noise exposure could reverse cochlear synaptopathy in vivo ( Figure 1B ).

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