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Effects of Lasmiditan on Cardiovascular Parameters and Pharmacokinetics in Healthy Subjects Receiving Oral Doses of Propranolol.

Clin Pharmacol Drug Dev · 2020 · PMC7384162 · PMID 31950732

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an increasing trendno p-value reported
Mean hourly heart rate then showed an increasing trend towards predose levels, rising from 54.5 bpm at 2 to 3 hours postdose to 63.4 bpm at 3 to 4 hours postdose, before remaining relatively stable up through 12 hours postdose (range 62.3 to 68.8 bpm).

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