Continuous vs Routine Electroencephalogram in Critically Ill Adults With Altered Consciousness and No Recent Seizure: A Multicenter Randomized Clinical Trial.

Mortality in patients without cardiac arrest showed a nonsignificant trend favoring cEEG: the absolute difference of 4.5% lies at less than the targeted 14% but is similar to the 5% reported in the 2019 retrospective assessment. 12 This might orient on the sample size needed for a future trial, where a difference of 4% (for example, a decrease from 48% to 44%) would imply enrollment of 4872 analyzable patients without cardiac arrest (2-sided proportion test; P = .05; power = 0.8).

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