EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study.

As the altitude increased, there was a linear decreasing trend in GG and AG carriers and an increasing trend in AA carriers [ 31 ].

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Under the dominant model, subjects with the EPAS1 -rs6756667 GA/AA genotype were less likely to suffer from AMS-related GI symptoms ( OR = 0.53; 95% CI 0.32–0.89; P = 0.013), and the result was marginally significant after FDR correction ( Q = 0.052).

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