Glutamate in cancers: from metabolism to signaling.

Although there was a slight trend towards higher mGluR5 expression levels in cancer tissues than in adjacent normal tissues, GRM5 expression was not associated with survival of patients.

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Specifically, the mGluR4 and mGluR5 gene expression showed an increasing trend in carcinogenetic tissues, compared to that in normal tissue; whereas mGluR3 gene was down regulated in renal cancer cells [ 85 ] .

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