highly significantP = 2.2E-16
DNMT1-Dependent DNA Methylation in Adult Interneurons Affects Degradative Pathways In stark contrast to the comparison of the 18 months old genotypes, we determined a highly significant overlap ( P = 2.2E-16, Fisher’s Exact test for gene set enrichment analysis; odds ratio = 0.434) of 645 genes between young control and Dnmt1 knockout interneurons, which display significant differences in both DNA methylation and gene expression ( Pensold et al., 2020 ).