Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression.

However, there was a nonsignificant trend toward retention of or switch to the mesenchymal subtype at recurrence across bulk/EN regions, consistent with other studies, 44 and suggesting some selection for this subtype with treatment. 29 , 39 While spatial dynamics have been less well studied, intratumoral transcriptional subtype heterogeneity has been previously demonstrated. 39 Our data revealed a significant switch toward a proneural subtype among NE regions as compared to bulk/EN.

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