Genetic background mutations drive neural circuit hyperconnectivity in a fragile X syndrome model.

Quantification shows controls have 7.8 ± 1.0 projections/bend whereas dfmr1 nulls have 17.8 ± 1.2, a highly significant elevation ( p = 1.3 × 10 −6 , two-tailed unpaired t test; Fig. 3 b, left).

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