Contemporary Pharmacologic Management of Heart Failure with Reduced Ejection Fraction: A Review.

Curr Cardiol Rev · 2020 · PMC7393599 · PMID 31288726

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an observed trendno p-value reported

On the basis of an observed trend towards increased survival with the combination of isosorbide dintrate and hydralazine in patients with HFrEF in the Vasodilator Heart Failure Trial (V-HeFT) 1986, the V-HeFT II trial (1992), randomized patients with primarily NYHA II-III HFrEF on diuretics and digoxin at baseline to enalapril or isosorbide dintrate/hydralazine.

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