highly significantp -value ≤ 10 −9
To simplify the interconnectivity between pathways and gene sets in the Circos plot, we performed filtering of data sets based on (1) limiting the KEGG pathways that are enriched for more than 10 genes ( n > 10) and (2) limiting the gene sets whose enrichment was highly significant (FDR p -value ≤ 10 −9 , the genome wide significance).