Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS.

J Exp Med · 2020 · PMC7398175 · PMID 32484501

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did not quite reach statistical significanceno p-value reported

Whereas MNs expressing inhPSAM showed an increased burden of LC3A and misfSOD1 accumulation (although the latter did not quite reach statistical significance in the present work) compared with noninfected MNs ( Saxena et al., 2013 ), MNs expressing D(Gs) displayed a reduced load of both disease markers ( Fig. 6, D and E ).

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