Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis.

Quantitative analyses confirmed that the Mrp2 immunogold labelling density in Wortmannin-inhibited samples remained as high as in controls despite insulin stimulation, while insulin also in the new media conditions with DMSO still led to a highly significant ( P = 0.0007 vs. control and P < 0.0001 vs. insulin + Wortmannin-treated cells) decline of Mrp2 levels at the plasma membrane (Fig. 5 h).

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