Cytotoxicity of the Sesquiterpene Lactones, Ivalin and Parthenolide in Murine Muscle Cell Lines and Their Effect on Desmin, a Cytoskeletal Intermediate Filament.

The overall logistic fit between percentage toxicity (Y) and log concentration of ivalin (X) was highly significant ( p < 0.001) for all the different exposure times.

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Although the increase in susceptibility of H9c2 cells to parthenolide, over time, was not as noticeable as compared with ivalin, based on the statistical ranges of the EC 50 s, there was a definite trend ( Table 1 ).

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