Accurate In-Vivo Quantification of CD19 CAR-T Cells after Treatment with Axicabtagene Ciloleucel (Axi-Cel) and Tisagenlecleucel (Tisa-Cel) Using Digital PCR.

As shown in Figure 2 a,b for the universal assay, we found a highly significant correlation (R 2 = 1.000, p < 0.0001 without; R 2 = 0.998, p < 0.0001 with added third-party DNA) between the numbers of HCK and axi-cel copies up to the lowest concentration.

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