Transglutaminase-2 regulates Wnt and FoxO3a signaling to determine the severity of osteoarthritis.

Although ZDON resulted in an increasing trend in both total β-catenin and non-phosphorylated β-catenin in the presence or absence of TGFβ1, the canonical Wnt signaling target proteins Axin2 and Tcf1 were not affected or were instead decreased by ZDON at the protein level.

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