Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies.

Finally, the equation describing the relationship between CRM A titer ( Y ) and the necessary three variables (soluble starch/ X 1 , yeast extract/ X 2 and (NH 4 ) 2 SO 4 / X 5 ) was confirmed as follow: Y = 572.72 - 80.09 X 1 + 71.51 X 2 - 58.55 X 5 - 59.29 X 1 2 - 56.39 X 2 2 - 1.8 X 1 X 2 - 41.4 X 1 X 5 - 10.19 X 2 X 5 Additionally, the reliability of the above-obtained model was tested as highly significant by analysis of variance (ANOVA) of CRM A titer to draw high F -value and low p value (0.00 or < 0.05) in regression coefficient validation (Table 1 ).

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