There has been an increasing trend of patients presenting with decreasing cure rates and frequent relapses within a few days to weeks of stopping the treatment with antifungal agents.
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Skin Barrier Function Defect - A Marker of Recalcitrant Tinea Infections.
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This was supported by a study, where dermatophytoses, except tinea pedis and tinea mannum, showed highly significant increase in TEWL compared with adjacent infection free skin.[ 15 ] In the context of our study, either the fungal strain is more invasive resulting into acceleration of the above process and not responding well to treatment, or, the barrier defect may be a primary phenomenon, which needs confirmation by further studies.