A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis.

Nat Commun · 2020 · PMC7414116 · PMID 32769986

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.1250

boldest claim

The sentences

borderline significancep = 0.053so close (0.05 < p ≤ 0.1)

hsa-let-7d-3p was also included because its levels were elevated in sCJD blood, albeit with borderline significance (FC 1.94, adjusted p = 0.053).

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fell short of significancep = 0.125not close (p > 0.1)

However, expression of hsa-miR-106b-3p was too low to allow replication by qPCR, and the adjusted p -value for hsa-miR-25-3p fell short of significance ( p = 0.125, Supplementary Data 1 ).

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