In the present study, an ordered trend in the frequency of the APOE e4 allele was observed: AD (30.8%), L-aMCI (24.0%), E-aMCI (15.1%), SMI (11.7%), and control (9.1%) groups, suggesting that there is an increasing trend in the frequency of APOE e4 alleles in the AD spectrum.
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Distribution and clinical impact of apolipoprotein E4 in subjective memory impairment and early mild cognitive impairment.
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