Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.

We also found that while the germline VGF overexpression DE signature (Supplementary Data 6 ) did not achieve significance at FDR < 0.05, DE genes at p value < 0.1 were enriched downstream of VGF in the gene BN (Supplementary Fig. 8 , one-sided Fisher’s exact test OR = 3.9, p value = 2.6e − 3).

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