Signaling via the p75 neurotrophin receptor facilitates amyloid-β-induced dendritic spine pathology.

500 nM Aβ 1–42 ), 23.1 ± 2.4% (mean ± SEM; n = 23) of wild type dendritic spines were associated with amyloid-β-immunoreactive puncta, whereas in contrast spines from p75 NTR ko neurons showed a colocalization ratio of only 6.9 ± 1.1% (mean ± SEM; n = 24), a difference that was statistically highly significant (p < 0.0001).

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