Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration.

Invest Ophthalmol Vis Sci · 2020 · PMC7415286 · PMID 32516404

Europe PMC DOI

hedged sentence

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

a trend toward significanceP = 0.063so close (0.05 < p ≤ 0.1)

Multiple regression analyses demonstrated a significant association between early AMD (OR 2.6, P = 0.01) and a decrease in FI level (per one unit on the ln scale) in patients with no CFI variant, whereas there was a trend toward significance in the any AMD group (OR 1.66, P = 0.063).

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