<i>In vitro</i> Activity of Robenidine Analog NCL195 in Combination With Outer Membrane Permeabilizers Against Gram-Negative Bacterial Pathogens and Impact on Systemic Gram-Positive Bacterial Infection in Mice.

Front Microbiol · 2020 · PMC7417630 · PMID 32849325

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an increasing trendno p-value reported

However, while there is an increasing trend of multidrug resistance in both Gram-negative and Gram-positive bacteria, there has been a significant global decline of investment into new drug development ( Livermore, 2012 ; Woolhouse and Farrar, 2014 ).

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