A Single Radioprotective Dose of Prostaglandin E₂ Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells.

Maintenance of HSC quiescence by dmPGE 2 may be significant for protection, since the portion of HSCs in active cell cycle is less capable of reconstitution upon transplant into the lethally irradiated environment compared with those in G 0 /G 1 ( Fleming et al., 1993 ).

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