Significant reduction of Sfpi1 expression evident in wild-type Sfpi1 R235 AML Wild-type Sfpi1 R235 samples had, on average, a clearly significantly lower transcriptional expression level of Sfpi1 when compared with samples with a R235 mutation ( Figure 3A ).
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Kras mutations and PU.1 promoter methylation are new pathways in murine radiation-induced AML.
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