Reduced axonal caliber and structural changes in a rat model of Fragile X syndrome with a deletion of a K-Homology domain of Fmr1.

Unexpectedly, while there were no significant interactions between genotype and sex after correcting for multiple comparisons, there were highly significant effects of sex on these DTI metrics in each region where FA (Supplementary Fig. 4A ; LM, p = 0.0029, p = 5.25 × 10 −5 , p = 7.71 × 10 −4 ), MD (Supplementary Fig. 4B ; Tukey HSD, p adj . 2.83 × 10 −10 ), and RD parameters (Supplementary Fig. 4C ; LM, p = 4.04 × 10 −9 and Tukey HSD, p adj . < 1.0 × 10 −20 ) were all higher in the males.

also in 132,142 other papers