Hence, these results justified the strategy to restrict the main analysis to the 8 h nocturnal period (23:00 h to 07:00 h). Irrespective of the dose used, IL-2 caused a highly significant rise in cortisol concentrations, both in older and young subjects, here quantified by the AUC during the nocturnal time period.
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Interleukin-2 drives cortisol secretion in an age-, dose-, and body composition-dependent way.
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