Recombinant Lactobacillus acidophilus expressing S₁ and S₂ domains of porcine epidemic diarrhea virus could improve the humoral and mucosal immune levels in mice and sows inoculated orally.

Comparison of antibody titers and cytokine levels at each time point were conducted by a paired t-test and the values are presented as mean ± standard deviation (SD), with p < 0.05 and p < 0.01 considered as statistically significant and highly significant, respectively.

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