Jude, revealed highly significant associations with two relatively common variants in glutamate NMDA receptor subunit 3A (GRIN3A) (rs10989692) and glutamate ionotropic receptor kainate type subunit 1 (GRIK1) (rs2154490) . 86 Notably, compelling evidence showed the GRIN3A variant to be involved in various vascular phenotypes, including cerebral ischemia, arterial embolism and thrombosis. 86 In 2016, a GWAS was performed to assess the risk of osteonecrosis in children less than 10 years of age with ALL.
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Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia.
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