FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.

Proc Natl Acad Sci U S A · 2020 · PMC7431096 · PMID 32719125

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hedged sentence

0.0210

closest p · 0.4× alpha

0.0210

boldest claim

The sentences

of borderline significanceP = 0.021actually significant

In comparison with the siNT control, transfection with siFEN1 resulted in a significant decrease in colony numbers for the BRCA -deficient cell lines (PEO1, UWB1.289, HCC1937), whereas only one (OVCAR-3) of the three BRCA -proficient cell lines (PEO4, OV-90, OVCAR-3) showed a small decrease in colony number that was of borderline significance ( P = 0.021) ( Fig. 4 C ).

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