Synthesis of 3(2)-phosphonylated thiazolo[3,2-<i>a</i>]oxopyrimidines.

Of special interest is the design of molecules containing practically significant heteroaromatic rings and a biologically active and hydrolysis-resistant phosphonate group, as it has been reported that the combination of several pharmacophore fragments in one molecule can lead to a synergistic increase in biological activity or an additional variety of the latter [ 22 – 28 ].

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