Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline.

For α‐satellite DNA and LINE1, there were highly significant positive correlations (both at the single CpG and the regional level) between sperm methylation and donor's age (Table 1 and Table S3 ). 2.2 Sequence‐ and age‐dependent rDNA methylation and epimutation rates The haploid sperm genome is endowed with several hundred copies of the rDNA transcription unit.

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