A machine-vision approach for automated pain measurement at millisecond timescales.

Specifically, while an automated, objective approach to measure evoked mechanical pain behavior in rodents will be a highly significant contribution to the pain field and the authors have presented solid efforts toward this goal, several critical aspects of the PAWS system and its validation that would successfully elevate the approach to a level above the manual one published previously (Abdus-Saboor et al., t) remain underdeveloped or missing.

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