Strikingly, a highly significant 3-fold increase of liver-infiltrating neutrophils was found in macrophage-ablated irf8 morpholino-injected animals after brain-LPS injection at four dpf compared with the control brain-LPS animals, while brain-water injected controls had no neutrophil infiltration into the liver with or without macrophages ( Figure 4d ).
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Drainage of inflammatory macromolecules from the brain to periphery targets the liver for macrophage infiltration.
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