Hypercoagulability following COVID-19 infection: at what stage is it safe to do a free flap?

5 Elevated D-Dimer levels are frequently reported; elevated D-dimer at admission and an increasing trend during the course of COVID-19 illness, predicts development of acute respiratory distress syndrome (ARDS), ICU admission and mortality. 6 , 7 Other coagulation abnormalities include prothrombin time (PT) and activated partial thromboplastin time (APTT) prolongation, increased fibrin degradation products and, less commonly, disseminated intravascular coagulation (DIC). 8 D-dimer elevation may also occur in asymptomatic individuals testing positive for COVID-19, 9 possibly representing a subclinical hypercoagulable state.

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