Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions.

GC5023 cells showed an almost significant reduction of firm adhesions on hESel after sLeX blockade ( P = 0.055). sLeX blockade experiments with sLeX-positive tumor cells In case of the sLeX-positive group ( Supplementary Figure 2C and D ), the sLeX blockade reduced static hESel binding (−73.3% to −92.2%), while mESel binding was again largely unaffected except for Molm13 cells showing a 33% reduction in mESel binding.

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