Although traditionally associated with the response to osmotic stress 29 , we observed an increase in TonEBP/NFAT5 expression in skin, lungs and (borderline significant) liver in SHRSP -HS, as well as in myocardium of aged SHRSP , despite the lack of hypertonicity (Fig. 2b and Supplementary Fig. 5 ).
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Tissue sodium excess is not hypertonic and reflects extracellular volume expansion.
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