close to significanceP < 0.1
78, P = 0.017), physical activity more than 30 min/day (Beta = − 0.4 95%CI:-0.8–0, P = 0.05), CED history (Beta = 0.49 95%CI:0.1–0.89, P = 0.015), MMSE score at baseline (Beta = 0.56 95%CI:0.47–0.64, P < 0.001), and HBA1c ≥8% (Beta = 0.61 95%CI:0.08–1.14, P = 0.024). Factors that had a level at or close to significance ( P < 0.1) were then included in multivariate analysis for independent factors related to MMSE decline (Table 3 ).