Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

While the trends are similar across segments, linkers, and loops; the enrichment of mild variants in termini contributed to a marginally significant difference in the cumulative distribution as measured by the Anderson-Darling test (p = 0.055) ( S3 Fig ).

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