Diagnosis and Management of Patients with Heart Failure with Preserved Ejection Fraction (HFpEF): Current Perspectives and Recommendations.

The worsening of renal function was 1.4% and 2.7% respectively (hazard ratio, 0.50; 95% CI, 0.33 to 0.77).The results of the Phase III PARAGON-HF study showed a 13% relative reduction in the primary composite endpoint of cardiovascular death and total (first and recurrent) heart failure hospitalizations, but narrowly missed statistical significance. 98 Sodium-glucose co-transporter-2 inhibitors (SGLT-2is) have significantly improved HF outcomes in patients with diabetes mellitus type 2 (T2D) and may represent a new therapeutic alternative for patients with T2D at risk for or with HF.

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