Even so, he was able to show a highly significant symptom reduction in both active groups as compared to placebo. 21 The correct sample calculation and the detailed description of randomization, blinding, and drop-outs make this study even today rated as moderately high scientific quality with low risk of bias. 22 Two decades later, extracts started to be standardized, and by the end of the 1980s many European extracts started to be alum-adsorbed, aiming to enhance immunogenicity, reduce allergenicity, and obtain a depot effect that would permit augmenting the dosing interval.
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Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines.
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