The physiological relevance of this reduction in carboxyhemoglobin may not be significant but taken together with low heme oxygenase-1 levels, it may be postulated that this cohort has diminished endogenous carbon monoxide production, which may influence the inflammatory status of these individuals and also reduce β-endorphins.
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Heme attenuates beta-endorphin levels in leukocytes of HIV positive individuals with chronic widespread pain.
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