145 , 146 By way of illustration, increased expression levels of EZH2 phosphorylated on serine 21 and KDM6A and reduced BMI1 protein in E6/E7-expressing human foreskin keratinocytes might be significant for cancer initiation and progression. 147 E7 protein in HPV-31 binds to and inhibits HDACs, thus enhancing viral replication by activating E2F2 transcription. 148 E6 oncoprotein inhibits p300-mediated acetylation on p53 and nucleosomal core histones, which mediates repression of p53 transactivation. 149 Hence, targeting some members of the epigenetic machinery could play a role in controlling HPV infection and/or HPV-preneoplastic or neoplastic changes.
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