Upper Respiratory Tract Viral Ribonucleic Acid Load at Hospital Admission Is Associated With Coronavirus Disease 2019 Disease Severity.

More severe patients seem to have the following characteristics: older age; higher frequency with underlying diseases; higher maximum body temperature within 24 hours after hospitalization; longer time for virus clearance (from illness onset to turning negative) and duration of fever (days); higher plasma C-reactive protein (CRP), D-dimer, procalcitonin (PCT), and aspartate aminotransferase (AST); larger count of white blood cells (WBC) and neutrophil (NE), but relatively reduced lymphocyte count (marginally significant; P = .095); higher NE to lymphocyte ratio (NLR); and higher initial viral load (Ct and log 10 [copies/mL]) (except lymphocyte [ P = .095], all P < .05) ( Table 1 ).

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