Furthermore, a previously published signature of Ras/MAPK activation exhibited a positive correlation with the glucose transporter SLC2A3 (GLUT3) and a nonsignificant trend toward positive correlation with the glucose transporter SLC2A1 (GLUT1), both of which are necessary for glycolysis, in publicly available TNBC The Cancer Genome Atlas (TCGA) data ( Supplemental Figure 6 ) ( 32 ).
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MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC.
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