Occludin and Claudin-4 mRNA levels displayed a decreasing trend in DSS-treated Ch25h -deficient mice (Fig. 3 A).
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Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function.
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ZO-2, Occludin, Claudin-1, Claudin-3 and Claudin-4 mRNA levels displayed an increasing trend in 25-HC- and DSS-treated mice compared to DSS-treated mice (Fig. 5 D).