Molecular Evolutionary Analysis of Nematode Zona Pellucida (ZP) Modules Reveals Disulfide-Bond Reshuffling and Standalone ZP-C Domains.

This was done for three reasons: 1) using a common template facilitated aligning and comparing models generated for different sequences; 2) models built using this template were usually the best option according to RaptorX’s internal ranking system (first place in 34/43 cases and second place in the rest, and always with highly significant model quality P values; supplementary table 5 , Supplementary Material online); and 3) human uromodulin possesses all three of the putatively typical ZP-C disulfide bonds defined by Bokhove et al.

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