highly significantP ≤ 0.001
Sod ntr injection caused a highly significant upregulation of HIF-1 α mRNA expression compared with its values of the control one (P ≤ 0.001), while pre-injection with Quer and Mel either alone or in combination produced a highly significant depletion of this expression matched with Sod ntr-injected rats (P ≤ 0.001) ( Figure 4 ).